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一架老旧的波音747飞机准备进行其最后一次夜间飞行，载着仅有的九位乘客从位于太平洋中心的好运岛飞往新加坡。由于乘客的锐减，该航线已经被取消。飞机起飞后，怪事便不断在这趟最后的航班上发生，先是土著老太突发癫狂非要带孙女下机；又是商务舱电视屏幕离奇中断；接着又是自闭症女孩举止诡异，最后连空姐杰西卡也神秘失踪……不安的气氛开始在机舱里蔓延，直至杰西卡被发现惨死在洗手间，身上留有奇怪的伤痕，飞机上仅有的十四个人开始陷入恐慌之中，而这时危险也正一步步地逼近……。The best man at Scott (Long) and Kristin's (Weixler) Arizona destination wedding, Lumpy (Labine) is the life of the party, until a long, indulgent night leads to his untimely death. Forced to cancel their honeymoon and fly back to Minneapolis to arrange for his funeral, Scott and Kristin meet Ramsey (Timlin) and learn that Lumpy isn't quite who they thought he was.。A young, determined sheriff and his posse chase a gang of murderous train robbers, and a kidnapped woman into New Mexico.@。